BIOSYNTHESIS OF THE PURINES
نویسندگان
چکیده
منابع مشابه
Biosynthesis of the purines.
4-Amino-5-imidazolecarboxamide (l), an amine found to accumulate in bacterial systems poisoned either by sulfonamides (2, 3) or aminopterin (4), has been suggested as an intermediate of purine synthetic reactions (5, 6). Although the metabolic inertness of the carboxamide’ in certain bacterial systems (7, 8) led to the belief by some (8) that this compound was an aberrant product of metabolism ...
متن کاملThe utilization of purines in the biosynthesis of folic acid.
There is little information on the origin of the pteridine ring of folic acid (1). The possibility that purines contribute to the biosynthesis of this part of the vitamin has been investigated earlier but could not be demonstrated in a number of microorganisms (2). In fact, attempts to demonstrate the conversion of purines to other naturally occurring pteridines have resulted in an impressive n...
متن کاملUtilization of the imidazole carbon 2 of histidine for the biosynthesis of purines in bacteria.
Histidine is converted by extracts of liver tissue and by extracts of histidine-grown bacteria to the same product, L-C+ formamidinoglutaric acid (2-4). Liver extracts catalyze the formylation of tetrahydrofolic acid by this compound (5, 6) and the transfer of the formyl group from formyltetrahydrofolic acid to the purine precursors N-glycyl-5-phosphoribofuranosylamine, and 4-amino-5-imidazole-...
متن کاملThe effect of purines on the formation of two enzymes involved in purine biosynthesis.
In many instances the end product of a sequence of biosynthetic reactions inhibits the formation of enzymes responsible for these reactions. Such “negative feedback” effects have been observed in bacteria for amino acids (3-6) and for pyrimidines (7), and the name “enzyme repression” has been coined for them (5). In the case of several amino acids, enzyme repression could be demonstrated by sho...
متن کاملThe biosynthesis of nucleic acid components studied with C14. I. Purines and pyrimidines in the rat.
Studies of the metabolism of purines and pyrimidines have been made in a variety of ways. Man, rats, pigeons, yeast, Neurospora, and bacteria have been used as experimental organisms. Edson, Krebs, and Model (2) have shown that ammonia and lactate stimulate the production of hypoxanthine by pigeon liver slices. Ammonia labeled with N15 was shown by Barnes and Schoenheimer (3) to be utilized in ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1953
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)52328-6